The ENS is a unique part of the nervous system
•Mediates behavior of gut in absence of input from CNS.
–Most neurons not connected to CNS
•Lacks internal collagen
•Support from enteric glia
•Many neurons and many types of neuron
–Every class of neurotransmitter found in CNS is also in ENS
–More neurons than spinal cord
–More neurons than remainder of PNS
–Greatest phenotypic diversity in PNS