The GDNF family of growth factors activate Ret
•Ret is a receptor
tyrosine kinase that is expressed in the gut only by crest-derived cells.
•Activated by ligands that bind to co-receptors
•Ret stimulates proliferation early in development, is a chemoattractant for migrating crst-derived cells, and supports survival.
•Activated by ligands that bind to co-receptors
•Ret stimulates proliferation early in development, is a chemoattractant for migrating crst-derived cells, and supports survival.