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GROWTH FACTORS
AND EARLY TOOTH
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CYTODIFFERENTIATION
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BMP
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FGF
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Shh
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Wnt
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BMP
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FGF
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Shh
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Wnt
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Bu
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d
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2º Enamel
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knot
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BMP-4
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FGF-10
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Wnt
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BMP-4
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FGF-10
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Wnt
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Enamel
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knot
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• Reiterative use of
growth factors
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• Growth
factor actions on proliferation, differentiation,
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morphogenesis
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