GROWTH FACTORS AND EARLY TOOTH
CYTODIFFERENTIATION
BMP
FGF
Shh
Wnt
BMP
FGF
Shh
Wnt
Bu
d
Bell
Cap
2º Enamel
knot
BMP-4
FGF-10
Wnt
BMP-4
FGF-10
Wnt
Enamel
knot
• Reiterative use of growth factors
• Growth factor actions on proliferation, differentiation,
morphogenesis