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Blastula: Langman’s
Medical Embryology, 8th ed., TW Sadler Lippincott, Williams & Wilkins
(Philadelphia) 2000, p. 43 (revised) Also in Hamilton et al. Human Embryology
Williams and Wilkins Phil (1972)4th ed. P. 64 attributed to Hertig and Rock.
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Cobbled together by JWW,
epithelium is from gall bladder!
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Sheds zona pellucida
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Presumptive embryo side
first. Cyto (stem cells) ->
syncytio, the cell layer that will adhere.
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Mucus-coated microvillous
border non-adhesive, anti-infective
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Expression of MUC-1 up
regulated by Progesterone
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Cross-talk begins.
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Paracrine secretions from
embryo induce change in ectodomain of MUC1 - only healthy embryos
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L-selectin by
trophoblast,ligand receptor by endometrial epithelium
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Paracrine signals from
trophectoderm -> change in Terminal web, tJ and adhering jn,
redistribution of apical and basolateral domains - loss of basal lamina.
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Endometrium expresses alpha
v/beta3 integrin - cell surface adhesion molecule (decreased expression in
infertile women).
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