|
|
|
Langman’s Medical
Embryology, 8th ed., TW Sadler Lippincott, Williams & Wilkins
(Philadelphia) 2000, p. 50
|
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Humoral - B, unchanged
|
|
Tissue - T reduced, but
many uterine NK (uNK) in decidual basalis, but action blocked
|
|
Trophoblast - no
expression of the MHCI surface
markers (gene suppression or DNA methylation) which are required for T helper
and cytotoxic T cells.. HLA-G
(human leukocyte antigen) cells no NK effect. (Pre-eclampsia when no HLA-G)
|
|
AFP from trophoblast and
beta1-glycoprotein depress maternal immune response - locally and stimulate
decidual production of IL-10 which suppresses NK cells and stimulates HLA-G.
|
|
Fas ligand inhibits
inflammatory cells immuno-privileged, e.g., anterior chamber, breast cancer
cells too
|
