FGF-fibroblast growth factor
_Loss
of epithelial FGF receptor leads to loss of branching
_FGF10
in mice from mesenchyme binds to FGFR2 on
epithelial cells.
_Epithelial
Shh (sonic hedgehog) shuts off FGF10 from mesenchyme,
stopping growth. New buds form in Shh
negative areas that have persistent FGF10
production
_Other
FGF (e.g. FGF7) and other FGFR (e.g. FGFR3 and 4)
may play a similar role in later stages of
distal/alveolar lung development.