<?xml version="1.0" encoding="UTF-16"?>
<Presentation>
<pptaddin>Articulate Presenter version 5 Pro,build055</pptaddin>
<Filename>C:\Documents and Settings\sbpmd\Desktop\HD\HD VascDev Lecture 2006.ppt</Filename>
<LmsProperties>
<protocol>
<method/>
<version/>
</protocol>
<completion>
<method/>
<threshold/>
<target/>
</completion>
</LmsProperties>
<BuiltinProperties>
<Title><![CDATA[HD VascDev Lecture 2006]]></Title>
<BasePath>HD VascDev Lecture 2006</BasePath>
<PresenterName><![CDATA[]]></PresenterName>
<PresenterTitle><![CDATA[]]></PresenterTitle>
<PresenterCompany><![CDATA[]]></PresenterCompany>
<PresenterEmail><![CDATA[]]></PresenterEmail>
<PresenterBio><![CDATA[]]></PresenterBio>
<PresenterPhoto/>
</BuiltinProperties>
<References>
</References>
<Slides>
<Slide id="1">
<Filename>slide1.swf</Filename>
<BackgroundFile>bgsm1.swf</BackgroundFile>
<Title><![CDATA[Angiogenesis in Human Development														Jan Kitajewski					ICRC 217B,  ph 851-4688,  email:  jkk9]]></Title>
<SlideText><![CDATA[Angiogenesis in Human Development 							 							Jan Kitajewski 					ICRC 217B,  ph 851-4688,  email:  jkk9 	BACKGROUND READING: 	 	Vascular Development 			“Signaling Vascular Morphogenesis and Maintenance” 			Douglas Hanahan. Science 277: 48-50. in Perspectives.  (1997)  	   Notch and arterial specification  	“Notch Function in the Vasculature: insights from zebrafish, 	mouse and man” 	Carrie Shawber and Jan Kitajewski. BioEssays 3: 225-34 (2004)  Wnts and retinal angiogenesis 	 	“Wnt/Frizzled Signaling in the Vasculature: New Angiogenic Factors in Sight” 	Nestor Masckauchan and Jan Kitajewski. Physiology 21: 181-188 (2006) ]]></SlideText>
<Notes><![CDATA[]]></Notes>
<SlideTime>74</SlideTime>
<waitforuser>false</waitforuser>
<Hidden>false</Hidden>
<DisplayMode></DisplayMode>
<level>0</level>
<PlayListId>-1</PlayListId>
<framerate>30</framerate>
</Slide>
<Slide id="2">
<Filename>slide2.swf</Filename>
<BackgroundFile>bgsm1.swf</BackgroundFile>
<Title><![CDATA[Vascular Development]]></Title>
<SlideText><![CDATA[Vascular Development 							 						 Vasculogenesis = de novo tube formation Angiogenesis = sprouting of new tubes off of pre-existing tubes  Endothelial Cell = cell type that makes up and lines blood vessels Mural Cells = specialized cells that surround blood vessels Pericytes Smooth muscle cells  Angiogenic Factors Vascular Endothelial Growth Factor (VEGF-A, VEGF-B, PlGF, VEGF-C, VEGF-D Angiopoietins (Ang 1, Ang2, ………..) Notch ligands (Jagged1, Delta4)  ]]></SlideText>
<Notes><![CDATA[]]></Notes>
<SlideTime>115</SlideTime>
<waitforuser>false</waitforuser>
<Hidden>false</Hidden>
<DisplayMode></DisplayMode>
<level>0</level>
<PlayListId>-1</PlayListId>
<framerate>30</framerate>
</Slide>
<Slide id="3">
<Filename>slide3.swf</Filename>
<BackgroundFile>bgsm1.swf</BackgroundFile>
<Title><![CDATA[Slide 3]]></Title>
<SlideText></SlideText>
<Notes><![CDATA[]]></Notes>
<SlideTime>112</SlideTime>
<waitforuser>false</waitforuser>
<Hidden>false</Hidden>
<DisplayMode></DisplayMode>
<level>0</level>
<PlayListId>-1</PlayListId>
<framerate>30</framerate>
</Slide>
<Slide id="4">
<Filename>slide4.swf</Filename>
<BackgroundFile>bgsm1.swf</BackgroundFile>
<Title><![CDATA[Slide 4]]></Title>
<SlideText><![CDATA[1.5 day 2.5 day 2.0 day ]]></SlideText>
<Notes><![CDATA[]]></Notes>
<SlideTime>54</SlideTime>
<waitforuser>false</waitforuser>
<Hidden>false</Hidden>
<DisplayMode></DisplayMode>
<level>0</level>
<PlayListId>-1</PlayListId>
<framerate>30</framerate>
</Slide>
<Slide id="5">
<Filename>slide5.swf</Filename>
<BackgroundFile>bgsm1.swf</BackgroundFile>
<Title><![CDATA[Slide 5]]></Title>
<SlideText><![CDATA[Nature Biotechnology  22, 595 - 599 (2004)   Chemical suppression of a genetic mutation in a  zebrafish model of aortic coarctation  Randall T Peterson1, Stanley Y Shaw1, 2, Travis A Peterson1, David J Milan1, Tao P Zhong1, 3,  Stuart L Schreiber2, Calum A MacRae1 & Mark C Fishman1, 4   1   Developmental Biology Laboratory, Cardiovascular Research Center, Massachusetts General Hospital Nature Chemical Biology  1, 263-264 (2005) High-throughput assay for small molecules that  modulate zebrafish embryonic heart rate. Burns CG, David J Milan, Grande DJ, Rottbauer W, Calum A MacRae & Mark C Fishman Developmental Biology Laboratory, Cardiovascular Research Center, Massachusetts General Hospital  ]]></SlideText>
<Notes><![CDATA[]]></Notes>
<SlideTime>38</SlideTime>
<waitforuser>false</waitforuser>
<Hidden>false</Hidden>
<DisplayMode></DisplayMode>
<level>0</level>
<PlayListId>-1</PlayListId>
<framerate>30</framerate>
</Slide>
<Slide id="6">
<Filename>slide6.swf</Filename>
<BackgroundFile>bgsm1.swf</BackgroundFile>
<Title><![CDATA[Angiogenesis - Basement Membrane Breakdown]]></Title>
<SlideText><![CDATA[Angiogenesis - Basement Membrane Breakdown Smooth Muscle Cells Endothelium Basement Membrane Proteases Angiogenic Stimulus (VEGF) ]]></SlideText>
<Notes><![CDATA[]]></Notes>
<SlideTime>108</SlideTime>
<waitforuser>false</waitforuser>
<Hidden>false</Hidden>
<DisplayMode></DisplayMode>
<level>0</level>
<PlayListId>-1</PlayListId>
<framerate>30</framerate>
</Slide>
<Slide id="7">
<Filename>slide7.swf</Filename>
<BackgroundFile>bgsm1.swf</BackgroundFile>
<Title><![CDATA[Angiogenesis - Endothelial Cell Migration]]></Title>
<SlideText><![CDATA[Angiogenesis - Endothelial Cell Migration Endothelium Nascent Vascular Sprouts VEGF Smooth Muscle Cells Basement Membrane ]]></SlideText>
<Notes><![CDATA[]]></Notes>
<SlideTime>40</SlideTime>
<waitforuser>false</waitforuser>
<Hidden>false</Hidden>
<DisplayMode></DisplayMode>
<level>0</level>
<PlayListId>-1</PlayListId>
<framerate>30</framerate>
</Slide>
<Slide id="8">
<Filename>slide8.swf</Filename>
<BackgroundFile>bgsm1.swf</BackgroundFile>
<Title><![CDATA[Angiogenesis - Endothelial Cell Proliferation]]></Title>
<SlideText><![CDATA[Angiogenesis - Endothelial Cell Proliferation Endothelium VEGF Sprout Elongation Smooth Muscle Cells Basement Membrane ]]></SlideText>
<Notes><![CDATA[]]></Notes>
<SlideTime>72</SlideTime>
<waitforuser>false</waitforuser>
<Hidden>false</Hidden>
<DisplayMode></DisplayMode>
<level>0</level>
<PlayListId>-1</PlayListId>
<framerate>30</framerate>
</Slide>
<Slide id="9">
<Filename>slide9.swf</Filename>
<BackgroundFile>bgsm1.swf</BackgroundFile>
<Title><![CDATA[Angiogenesis - Capillary Morphogenesis]]></Title>
<SlideText><![CDATA[Angiogenesis - Capillary Morphogenesis Endothelium VEGF New Lumen Formation Smooth Muscle Cells Basement Membrane ]]></SlideText>
<Notes><![CDATA[]]></Notes>
<SlideTime>43</SlideTime>
<waitforuser>false</waitforuser>
<Hidden>false</Hidden>
<DisplayMode></DisplayMode>
<level>0</level>
<PlayListId>-1</PlayListId>
<framerate>30</framerate>
</Slide>
<Slide id="10">
<Filename>slide10.swf</Filename>
<BackgroundFile>bgsm1.swf</BackgroundFile>
<Title><![CDATA[Slide 10]]></Title>
<SlideText><![CDATA[Angiogenesis - Vascular Maturation Endothelium VEGF Vascular Pruning (apoptosis?) SMC, pericyte recruitment Smooth Muscle Cells Basement Membrane ]]></SlideText>
<Notes><![CDATA[]]></Notes>
<SlideTime>77</SlideTime>
<waitforuser>false</waitforuser>
<Hidden>false</Hidden>
<DisplayMode></DisplayMode>
<level>0</level>
<PlayListId>-1</PlayListId>
<framerate>30</framerate>
</Slide>
<Slide id="11">
<Filename>slide11.swf</Filename>
<BackgroundFile>bgsm1.swf</BackgroundFile>
<Title><![CDATA[Angiogenesis - Vascular Maturation]]></Title>
<SlideText><![CDATA[Angiogenesis - Vascular Maturation Endothelium VEGF Endothelial cell-cell junctions Smooth Muscle Cells Basement Membrane Negative Feedback ]]></SlideText>
<Notes><![CDATA[]]></Notes>
<SlideTime>58</SlideTime>
<waitforuser>false</waitforuser>
<Hidden>false</Hidden>
<DisplayMode></DisplayMode>
<level>0</level>
<PlayListId>-1</PlayListId>
<framerate>30</framerate>
</Slide>
<Slide id="12">
<Filename>slide12.swf</Filename>
<BackgroundFile>bgsm1.swf</BackgroundFile>
<Title><![CDATA[VEGF and VEGF Receptors]]></Title>
<SlideText><![CDATA[VEGF and VEGF Receptors ]]></SlideText>
<Notes><![CDATA[]]></Notes>
<SlideTime>152</SlideTime>
<waitforuser>false</waitforuser>
<Hidden>false</Hidden>
<DisplayMode></DisplayMode>
<level>0</level>
<PlayListId>-1</PlayListId>
<framerate>30</framerate>
</Slide>
<Slide id="13">
<Filename>slide13.swf</Filename>
<BackgroundFile>bgsm1.swf</BackgroundFile>
<Title><![CDATA[VEGF-receptor signaling]]></Title>
<SlideText><![CDATA[VEGF-receptor  signaling ]]></SlideText>
<Notes><![CDATA[]]></Notes>
<SlideTime>67</SlideTime>
<waitforuser>false</waitforuser>
<Hidden>false</Hidden>
<DisplayMode></DisplayMode>
<level>0</level>
<PlayListId>-1</PlayListId>
<framerate>30</framerate>
</Slide>
<Slide id="14">
<Filename>slide14.swf</Filename>
<BackgroundFile>bgsm1.swf</BackgroundFile>
<Title><![CDATA[Slide 14]]></Title>
<SlideText></SlideText>
<Notes><![CDATA[]]></Notes>
<SlideTime>175</SlideTime>
<waitforuser>false</waitforuser>
<Hidden>false</Hidden>
<DisplayMode></DisplayMode>
<level>0</level>
<PlayListId>-1</PlayListId>
<framerate>30</framerate>
</Slide>
<Slide id="15">
<Filename>slide15.swf</Filename>
<BackgroundFile>bgsm1.swf</BackgroundFile>
<Title><![CDATA[Slide 15]]></Title>
<SlideText><![CDATA[Vasculogenesis Lymphangiogenesis Angiogenesis Mesoderm formation Hemangioblasts  Blood island formation Endothelial cells Hematopoietic  cells Primary vascular  plexus Lymphatics Lymphangioblasts Veins Capillaries Arteries VE-Cadherin bFGF VEGF A VEGFR-1/2/3 TGFb EphrinB2/EphB4 Endoglin		Notch Tal1/scl Gata 1 Ang1/2 Tie2 PDGF B Id1/3 VEGF C/D VEGFR-3 VEGF A VEGFR-2 TGFb Tal1/scl Gata 1 Vascular Development Karkkarnin et al., 2002 Nature Cell Biology GM-CSF Notch on Notch off ]]></SlideText>
<Notes><![CDATA[]]></Notes>
<SlideTime>154</SlideTime>
<waitforuser>false</waitforuser>
<Hidden>false</Hidden>
<DisplayMode></DisplayMode>
<level>0</level>
<PlayListId>-1</PlayListId>
<framerate>30</framerate>
</Slide>
<Slide id="16">
<Filename>slide16.swf</Filename>
<BackgroundFile>bgsm1.swf</BackgroundFile>
<Title><![CDATA[Slide 16]]></Title>
<SlideText><![CDATA[Mailhos, 2001 Shutter, 2000 Notch/Notch ligands expressed  in arterial endothelium ]]></SlideText>
<Notes><![CDATA[]]></Notes>
<SlideTime>100</SlideTime>
<waitforuser>false</waitforuser>
<Hidden>false</Hidden>
<DisplayMode></DisplayMode>
<level>0</level>
<PlayListId>-1</PlayListId>
<framerate>30</framerate>
</Slide>
<Slide id="17">
<Filename>slide17.swf</Filename>
<BackgroundFile>bgsm1.swf</BackgroundFile>
<Title><![CDATA[Slide 17]]></Title>
<SlideText></SlideText>
<Notes><![CDATA[]]></Notes>
<SlideTime>58</SlideTime>
<waitforuser>false</waitforuser>
<Hidden>false</Hidden>
<DisplayMode></DisplayMode>
<level>0</level>
<PlayListId>-1</PlayListId>
<framerate>30</framerate>
</Slide>
<Slide id="18">
<Filename>slide18.swf</Filename>
<BackgroundFile>bgsm1.swf</BackgroundFile>
<Title><![CDATA[VEGF and VEGF Receptors]]></Title>
<SlideText><![CDATA[VEGF and VEGF Receptors ]]></SlideText>
<Notes><![CDATA[]]></Notes>
<SlideTime>20</SlideTime>
<waitforuser>false</waitforuser>
<Hidden>false</Hidden>
<DisplayMode></DisplayMode>
<level>0</level>
<PlayListId>-1</PlayListId>
<framerate>30</framerate>
</Slide>
<Slide id="19">
<Filename>slide19.swf</Filename>
<BackgroundFile>bgsm1.swf</BackgroundFile>
<Title><![CDATA[Slide 19]]></Title>
<SlideText></SlideText>
<Notes><![CDATA[]]></Notes>
<SlideTime>92</SlideTime>
<waitforuser>false</waitforuser>
<Hidden>false</Hidden>
<DisplayMode></DisplayMode>
<level>0</level>
<PlayListId>-1</PlayListId>
<framerate>30</framerate>
</Slide>
<Slide id="20">
<Filename>slide20.swf</Filename>
<BackgroundFile>bgsm1.swf</BackgroundFile>
<Title><![CDATA[Slide 20]]></Title>
<SlideText><![CDATA[Structure of blood and lymphatic vasculature in dermis normal + lymphatics - lymphatics Mouse with mutation in VEGFR-3 blood vessel lymphatic vessel ]]></SlideText>
<Notes><![CDATA[]]></Notes>
<SlideTime>88</SlideTime>
<waitforuser>false</waitforuser>
<Hidden>false</Hidden>
<DisplayMode></DisplayMode>
<level>0</level>
<PlayListId>-1</PlayListId>
<framerate>30</framerate>
</Slide>
<Slide id="21">
<Filename>slide21.swf</Filename>
<BackgroundFile>bgsm1.swf</BackgroundFile>
<Title><![CDATA[Slide 21]]></Title>
<SlideText></SlideText>
<Notes><![CDATA[]]></Notes>
<SlideTime>54</SlideTime>
<waitforuser>false</waitforuser>
<Hidden>false</Hidden>
<DisplayMode></DisplayMode>
<level>0</level>
<PlayListId>-1</PlayListId>
<framerate>30</framerate>
</Slide>
<Slide id="22">
<Filename>slide22.swf</Filename>
<BackgroundFile>bgsm1.swf</BackgroundFile>
<Title><![CDATA[Slide 22]]></Title>
<SlideText></SlideText>
<Notes><![CDATA[]]></Notes>
<SlideTime>75</SlideTime>
<waitforuser>false</waitforuser>
<Hidden>false</Hidden>
<DisplayMode></DisplayMode>
<level>0</level>
<PlayListId>-1</PlayListId>
<framerate>30</framerate>
</Slide>
<Slide id="23">
<Filename>slide23.swf</Filename>
<BackgroundFile>bgsm1.swf</BackgroundFile>
<Title><![CDATA[Slide 23]]></Title>
<SlideText></SlideText>
<Notes><![CDATA[]]></Notes>
<SlideTime>31</SlideTime>
<waitforuser>false</waitforuser>
<Hidden>false</Hidden>
<DisplayMode></DisplayMode>
<level>0</level>
<PlayListId>-1</PlayListId>
<framerate>30</framerate>
</Slide>
<Slide id="24">
<Filename>slide24.swf</Filename>
<BackgroundFile>bgsm1.swf</BackgroundFile>
<Title><![CDATA[Slide 24]]></Title>
<SlideText></SlideText>
<Notes><![CDATA[]]></Notes>
<SlideTime>30</SlideTime>
<waitforuser>false</waitforuser>
<Hidden>false</Hidden>
<DisplayMode></DisplayMode>
<level>0</level>
<PlayListId>-1</PlayListId>
<framerate>30</framerate>
</Slide>
<Slide id="25">
<Filename>slide25.swf</Filename>
<BackgroundFile>bgsm1.swf</BackgroundFile>
<Title><![CDATA[Slide 25]]></Title>
<SlideText></SlideText>
<Notes><![CDATA[]]></Notes>
<SlideTime>65</SlideTime>
<waitforuser>false</waitforuser>
<Hidden>false</Hidden>
<DisplayMode></DisplayMode>
<level>0</level>
<PlayListId>-1</PlayListId>
<framerate>30</framerate>
</Slide>
<Slide id="26">
<Filename>slide26.swf</Filename>
<BackgroundFile>bgsm1.swf</BackgroundFile>
<Title><![CDATA[Slide 26]]></Title>
<SlideText></SlideText>
<Notes><![CDATA[]]></Notes>
<SlideTime>57</SlideTime>
<waitforuser>false</waitforuser>
<Hidden>false</Hidden>
<DisplayMode></DisplayMode>
<level>0</level>
<PlayListId>-1</PlayListId>
<framerate>30</framerate>
</Slide>
<Slide id="27">
<Filename>slide27.swf</Filename>
<BackgroundFile>bgsm1.swf</BackgroundFile>
<Title><![CDATA[Slide 27]]></Title>
<SlideText><![CDATA[Fruttinger, 2004 Delta4 expressed in retinal vasculature in situ hybridization arterial expression      tip cell expression ]]></SlideText>
<Notes><![CDATA[]]></Notes>
<SlideTime>50</SlideTime>
<waitforuser>false</waitforuser>
<Hidden>false</Hidden>
<DisplayMode></DisplayMode>
<level>0</level>
<PlayListId>-1</PlayListId>
<framerate>30</framerate>
</Slide>
<Slide id="28">
<Filename>slide28.swf</Filename>
<BackgroundFile>bgsm1.swf</BackgroundFile>
<Title><![CDATA[Slide 28]]></Title>
<SlideText></SlideText>
<Notes><![CDATA[]]></Notes>
<SlideTime>61</SlideTime>
<waitforuser>false</waitforuser>
<Hidden>false</Hidden>
<DisplayMode></DisplayMode>
<level>0</level>
<PlayListId>-1</PlayListId>
<framerate>30</framerate>
</Slide>
<Slide id="29">
<Filename>slide29.swf</Filename>
<BackgroundFile>bgsm1.swf</BackgroundFile>
<Title><![CDATA[Normal intraretinal vasculature]]></Title>
<SlideText><![CDATA[Normal intraretinal vasculature ]]></SlideText>
<Notes><![CDATA[]]></Notes>
<SlideTime>25</SlideTime>
<waitforuser>false</waitforuser>
<Hidden>false</Hidden>
<DisplayMode></DisplayMode>
<level>0</level>
<PlayListId>-1</PlayListId>
<framerate>30</framerate>
</Slide>
<Slide id="30">
<Filename>slide30.swf</Filename>
<BackgroundFile>bgsm1.swf</BackgroundFile>
<Title><![CDATA[Slide 30]]></Title>
<SlideText></SlideText>
<Notes><![CDATA[]]></Notes>
<SlideTime>124</SlideTime>
<waitforuser>false</waitforuser>
<Hidden>false</Hidden>
<DisplayMode></DisplayMode>
<level>0</level>
<PlayListId>-1</PlayListId>
<framerate>30</framerate>
</Slide>
<Slide id="31">
<Filename>slide31.swf</Filename>
<BackgroundFile>bgsm1.swf</BackgroundFile>
<Title><![CDATA[Slide 31]]></Title>
<SlideText><![CDATA[Retinopathy of Prematurity ]]></SlideText>
<Notes><![CDATA[]]></Notes>
<SlideTime>112</SlideTime>
<waitforuser>false</waitforuser>
<Hidden>false</Hidden>
<DisplayMode></DisplayMode>
<level>0</level>
<PlayListId>-1</PlayListId>
<framerate>30</framerate>
</Slide>
<Slide id="32">
<Filename>slide32.swf</Filename>
<BackgroundFile>bgsm1.swf</BackgroundFile>
<Title><![CDATA[Slide 32]]></Title>
<SlideText></SlideText>
<Notes><![CDATA[]]></Notes>
<SlideTime>26</SlideTime>
<waitforuser>false</waitforuser>
<Hidden>false</Hidden>
<DisplayMode></DisplayMode>
<level>0</level>
<PlayListId>-1</PlayListId>
<framerate>30</framerate>
</Slide>
<Slide id="33">
<Filename>slide33.swf</Filename>
<BackgroundFile>bgsm1.swf</BackgroundFile>
<Title><![CDATA[Slide 33]]></Title>
<SlideText></SlideText>
<Notes><![CDATA[]]></Notes>
<SlideTime>59</SlideTime>
<waitforuser>false</waitforuser>
<Hidden>false</Hidden>
<DisplayMode></DisplayMode>
<level>0</level>
<PlayListId>-1</PlayListId>
<framerate>30</framerate>
</Slide>
<Slide id="34">
<Filename>slide34.swf</Filename>
<BackgroundFile>bgsm1.swf</BackgroundFile>
<Title><![CDATA[Familial Exudative Vitreoretinopathy]]></Title>
<SlideText><![CDATA[Familial Exudative Vitreoretinopathy  First described by Criswick and Schepens [Am. J. Ophthalmol. 68: 578-594  (1969)] Autosomal dominant, recessive, and X-linked forms; variable phenotype Clinical characteristics 		mild to severe vision loss     		retina:  avascular peripheral retina, exudates, 		neovascularization, fibrovascular masses, 		traction or rhegmatogenous retinal detachment     		vitreous: posterior vitreous detachment,  		fibrovascular membranes, hemorrhage 		other: cataract, neovascular glaucoma   ]]></SlideText>
<Notes><![CDATA[]]></Notes>
<SlideTime>42</SlideTime>
<waitforuser>false</waitforuser>
<Hidden>false</Hidden>
<DisplayMode></DisplayMode>
<level>0</level>
<PlayListId>-1</PlayListId>
<framerate>30</framerate>
</Slide>
<Slide id="35">
<Filename>slide35.swf</Filename>
<BackgroundFile>bgsm1.swf</BackgroundFile>
<Title><![CDATA[Slide 35]]></Title>
<SlideText><![CDATA[Autosomal dominant FEVR mutations In the cysteine-rich domain (CRD) of Fz4 ]]></SlideText>
<Notes><![CDATA[]]></Notes>
<SlideTime>63</SlideTime>
<waitforuser>false</waitforuser>
<Hidden>false</Hidden>
<DisplayMode></DisplayMode>
<level>0</level>
<PlayListId>-1</PlayListId>
<framerate>30</framerate>
</Slide>
<Slide id="36">
<Filename>slide36.swf</Filename>
<BackgroundFile>bgsm1.swf</BackgroundFile>
<Title><![CDATA[Retinal defects in FEVR patients heterozygous for Fz4 M157V]]></Title>
<SlideText><![CDATA[Retinal defects in FEVR patients  heterozygous for Fz4 M157V ]]></SlideText>
<Notes><![CDATA[]]></Notes>
<SlideTime>29</SlideTime>
<waitforuser>false</waitforuser>
<Hidden>false</Hidden>
<DisplayMode></DisplayMode>
<level>0</level>
<PlayListId>-1</PlayListId>
<framerate>30</framerate>
</Slide>
<Slide id="37">
<Filename>slide37.swf</Filename>
<BackgroundFile>bgsm1.swf</BackgroundFile>
<Title><![CDATA[Slide 37]]></Title>
<SlideText><![CDATA[Frizzled-4 is a Wnt receptor ]]></SlideText>
<Notes><![CDATA[]]></Notes>
<SlideTime>36</SlideTime>
<waitforuser>false</waitforuser>
<Hidden>false</Hidden>
<DisplayMode></DisplayMode>
<level>0</level>
<PlayListId>-1</PlayListId>
<framerate>30</framerate>
</Slide>
<Slide id="38">
<Filename>slide38.swf</Filename>
<BackgroundFile>bgsm1.swf</BackgroundFile>
<Title><![CDATA[Intraocular hemorrhage in Fz4(-/-) mice]]></Title>
<SlideText><![CDATA[Intraocular hemorrhage in Fz4(-/-) mice ]]></SlideText>
<Notes><![CDATA[]]></Notes>
<SlideTime>29</SlideTime>
<waitforuser>false</waitforuser>
<Hidden>false</Hidden>
<DisplayMode></DisplayMode>
<level>0</level>
<PlayListId>-1</PlayListId>
<framerate>30</framerate>
</Slide>
<Slide id="39">
<Filename>slide39.swf</Filename>
<BackgroundFile>bgsm1.swf</BackgroundFile>
<Title><![CDATA[Absence of intra-retinal capillaries in Fz4(-/-) mice]]></Title>
<SlideText><![CDATA[Absence of intra-retinal capillaries in Fz4(-/-) mice                     WT                          -/- ]]></SlideText>
<Notes><![CDATA[]]></Notes>
<SlideTime>49</SlideTime>
<waitforuser>false</waitforuser>
<Hidden>false</Hidden>
<DisplayMode></DisplayMode>
<level>0</level>
<PlayListId>-1</PlayListId>
<framerate>30</framerate>
</Slide>
<Slide id="40">
<Filename>slide40.swf</Filename>
<BackgroundFile>bgsm1.swf</BackgroundFile>
<Title><![CDATA[Norrie Disease]]></Title>
<SlideText><![CDATA[Norrie Disease First described by Norrie (1927) and analyzed systematically  by Mette Warburg [Acta Ophthalmologica 39: 757-772 (1961); 41: 134-146 (1963); 89: 1-147 (1966)] X-linked recessive with variable phenotype Clinical characteristics 		moderate vision loss to congenital blindness 		retina: retinal folding and detachment, retinal 		degeneration, fibrovascualar masses, vitreoretinal 		hemorrhage 		vitreous: persistent primary vitreous 		other: progressive sensorineural deafness ]]></SlideText>
<Notes><![CDATA[]]></Notes>
<SlideTime>48</SlideTime>
<waitforuser>false</waitforuser>
<Hidden>false</Hidden>
<DisplayMode></DisplayMode>
<level>0</level>
<PlayListId>-1</PlayListId>
<framerate>30</framerate>
</Slide>
<Slide id="41">
<Filename>slide41.swf</Filename>
<BackgroundFile>bgsm1.swf</BackgroundFile>
<Title><![CDATA[Slide 41]]></Title>
<SlideText></SlideText>
<Notes><![CDATA[]]></Notes>
<SlideTime>38</SlideTime>
<waitforuser>false</waitforuser>
<Hidden>false</Hidden>
<DisplayMode></DisplayMode>
<level>0</level>
<PlayListId>-1</PlayListId>
<framerate>30</framerate>
</Slide>
<Slide id="42">
<Filename>slide42.swf</Filename>
<BackgroundFile>bgsm1.swf</BackgroundFile>
<Title><![CDATA[Slide 42]]></Title>
<SlideText><![CDATA[Norrin is a ligand for Frizzled-4 Norrin ]]></SlideText>
<Notes><![CDATA[]]></Notes>
<SlideTime>41</SlideTime>
<waitforuser>false</waitforuser>
<Hidden>false</Hidden>
<DisplayMode></DisplayMode>
<level>0</level>
<PlayListId>-1</PlayListId>
<framerate>30</framerate>
</Slide>
<Slide id="43">
<Filename>slide43.swf</Filename>
<BackgroundFile>bgsm1.swf</BackgroundFile>
<Title><![CDATA[Molecular genetics of Norrie Disease and FEVR]]></Title>
<SlideText><![CDATA[Molecular genetics of Norrie Disease and FEVR FEVR 	One autosomal dominant FEVR gene identified by Robaitaille et al [Nature Genetics 32: 326-330 (2002)] encodes Frizzled4, a putative Wnt receptor.  A second autosomal dominant FEVR locus encodes the Wnt co-receptor Lrp5 [Toomes et al [IOVS 45: 2083-2090 (2004)]; Jiao et al [Am J Hum Genet 75: 878-884 (2004)].  Norrie disease 	Gene identified by Berger et al and Chen et al [Nature Genetics 1: 199-203 and 204-208 (1992)] 	The encoded protein is small (133 amino acids in length), has the same pattern of cysteines as seen in transforming growth factor beta, and begins with a signal sequence (i.e. it looks like a secreted protein).  No known biochemical function.  ]]></SlideText>
<Notes><![CDATA[]]></Notes>
<SlideTime>42</SlideTime>
<waitforuser>false</waitforuser>
<Hidden>false</Hidden>
<DisplayMode></DisplayMode>
<level>0</level>
<PlayListId>-1</PlayListId>
<framerate>30</framerate>
</Slide>
<Slide id="44">
<Filename>slide44.swf</Filename>
<BackgroundFile>bgsm1.swf</BackgroundFile>
<Title><![CDATA[Vessel component to human disease]]></Title>
<SlideText><![CDATA[Vessel component to human disease Tumor angiogenesis Diabetic vascular complication Diabetic retinopathy Stroke Ischemia Wound repair Heart disease Obesity Blindness Wet Macular Degeneration Retinopathy of Prematurity ]]></SlideText>
<Notes><![CDATA[]]></Notes>
<SlideTime>91</SlideTime>
<waitforuser>false</waitforuser>
<Hidden>false</Hidden>
<DisplayMode></DisplayMode>
<level>0</level>
<PlayListId>-1</PlayListId>
<framerate>30</framerate>
</Slide>
</Slides>
</Presentation>
