Anatomical Substrates of
Somatic Sensation

"The 2 principal somatic"

Dorsal Column-Medial Lemniscal System

Anterolateral System

Perspective:

Dorsal column-medial lemniscal system: Mechanical sensations

Anterolateral system:
Pain, Thermal, Itch

Mechanoreceptors
are encapsulated

Nociceptors, thermoreceptors, & itch receptors are
bare nerve endings

Dorsal root ganglion neuron

Key Characteristics of DRG Neurons

Receptive field

CNS Neurons have Receptive Fields

Key Characteristics of DRG Neurons

Mechano-
receptor
receptive
fields

Mechano-
receptor
receptive
fields

Nociceptors, thermoreceptors, & itch receptors are
bare nerve endings

Nociceptors
respond to
noxious
stimuli

Peripheral
nerve
cross
section

Fiber Histogram: Sensory axon innervating the skin

Fiber Histogram: Sensory axon innervating a muscle

SC

Dermatomes

Dermatomes
overlap

Dermatomes
overlap

Dermatomes
overlap

Spinal cords

Receptor projections to systems

LgTermPatterns

DC lesion

Lg&SmTermPatterns

Lg&SmTermPatterns

Anterolateral system X

Spinal Hemisection

Syringomyelia

Somatotopy of spinal paths

Anterolateral
system

Somatic Sensory Thalamus

Slide 39

Slide 40

Slide 41

Brodmann’s
cytoarchitectonic
areas

Somatic Sensory Cortical Areas
for Mechanosensations

Slide 44

1° Somatic Sensory Cortex Output Systems

Cortical Pain Representations

Slide 47

Summary