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- There are
multiple types of nociceptors: they can differ by sensitivity to
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growth factors,
peptide expression, conduction velocity, sensory modality
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- All
nociceptors release glutamate thus glutamate receptors are potential
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targets for pain
management
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- Sensitization
occurs peripherally and centrally
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- Dorsal horn
neurons project to multiple higher levels in the brain and
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receive
descending regulatory input from those same areas
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- There are good
targets for pain management on peripheral and central
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terminals of
nociceptors as well as through regulation of inhibition in the
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dorsal horn
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