 |
|
|
|
|
|
|
|
|
|
|
|
| • |
The modern view
of energy homeostasis now proposes
|
|
|
that discrete
neuronal pathways generate integrated
|
|
|
responses to
afferent input related to energy storage.
|
|
|
The hypothalamus
plays a prominent role in this
|
|
|
integration.
|
|
|
| • |
The hypothalamus
is sensitive to adiposity signals
|
|
|
supplied by the
hormones leptin and insulin, secreted by
|
|
fat cells and the
pancrease respectively.
|
|
|
| • |
Insulin and
leptin both modulate neural activity in the
|
|
|
arcuate nucleus
of the hypothalamus, which transduces
|
|
|
afferent hormonal
signals into a neural response.
|
|