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Agrin -/-:
few ACh-R clusters, overshooting of axons
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MuSK -/-:
no ACh-R clusters, overshooting of axons
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Rapsyn -/-:
no ACh-R clusters, but higher receptor
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levels in
synaptic area, only limited overshooting
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| • |
Pre-synaptic
defects in all mutants, due to the lack of
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retrograde
signals from the muscle
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