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Mechanism for “winner-take-all” (open
eye) and synapse elimination (closed eye):
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-Cooperative,
synchronous firing and
competition (Hebb; LTP)
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-Postsynaptic NMDA receptors
open
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-Neurotrophins from
postsynaptic cell released and taken up by active
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presynaptic
terminals (ones that are strongly firing, cooperatively
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-Neurotrophins act on presynaptic axons,
axon arbors branch and expand
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