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| 3. Genetic approach |
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| Example
1: Wallerian degeneration of
injured axons and synapses |
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| is delayed by
a Ube4b/Nmnat* chimeric gene |
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| Distal segment
degenerates-24-48 hours |
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| Wildtype
transgenic mouse |
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| with Ube4b/Nmnat |
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|
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| *encodes nuclear
ubiquitination factor E4B fused to nicotinamide mononucleotide
adenylyltransferase; |
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| leads to neuroprotection by altering pyridine nucleotide metabolism. |
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