|
|
|
| Degree of Na+ Inactivation Deficit Determines |
||
| Whether Paralysis or Hyperexcitability Occurs |
||
|
|
| Na+
channels open, but |
|
| do
not inactivate normally |
|
| + |
| Firing |
| + + |
|
|
|
|
|
| Persistent |
||||
| inactivation of |
||||
| normal Na+ |
||||
| channels |
||||
| Paralysis |
||||
| [K+]o More positive EK |