Example of Gene transfer 1:
Instigate events that occur during development
by gene transfer genetically:
GAP-43 transgenic mice:
A.
B.
GAP-43 transgenic mice
show a 60-fold increase
in adult DRG axon
regeneration
into a peripheral nerve
graft, in the spinal cord
in vivo
+ GAP-43
In vitro
Bomze et al., 2001, Nat. Neurosci., 4: 38