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Classification of Epilepsy
Generalized
Convulsive (grand mal)
Nonconvulsive (petit mal)
Myoclonic
Febrile
Partial (focal)
P. seizures with elementary symptoms
P. seizures with complex symptoms
P. seizures with secondary generalization

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Complex partial seizures -localization
Orbital frontal
Olfactory hallucinations, autonomic phenomena.
Anterior temporal, amygdalar
Lip smaking, forced searching, blank staring, epigastric distress, respiratory irregularity.
Posterior temporal
Auditory, vestibular, and visual phenomena.
Temporal, limbic
Dysmnestic states (déjà vu, j’amais vu), dream states, mind-body dissociation, fear, panic, and anxiety.

Hippocampus

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Insights from genetics
Mendelian inheritance
Neonatal convulsions
Nocturnal frontal lobe epilepsy
Progressive myoclonic epilepsy
Cortical malformation syndromes
Complex inheritance (alters synaptic function, ion channels, neuronal structure

Molecular genetics of idiopathic epilepsies

"Lord,"
Lord, have mercy on my son, for he is an epileptic and he suffers terribly; for often he falls into the fire, and often into the water,
And I brought him to your disciples,
And they could not heal him.
                                               - Matthew 17:15-16

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"Both Pat and Shirley believe..."
Both Pat and Shirley believe that exorcism is a much-too-neglected therapy for the epileptic,
“What we call fits - seizures and epilepsy today” he explained, “Jesus recognized as possession by demons.  Jesus saw epilepsy for what it is - the work of Satan.”
Pat Boone Believes in Miracles
McCalls Magazine, February 1973, p. 122

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Pharmacotherapy
¯Burst firing (Na+ channel blockade)
Phenytoin, Carbamezapine, Felbamate, Topiramate
­Inhibition (GABA potentiation)
Barbituates, Benzodiazepines, Valproate, Gabapentin, Tiagabine, Topiramate
¯Coupling (Glutamate receptor antagonist)
Topiramate, Felbamate

Neuroimaging

Neuroimaging:
mesial temporal lobe sclerosis (Flair)

Neuroimaging: MTS (T2)

Gamma Knife Surgery

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