Sleep

	Neil B. Kavey, MD
	Columbia Presbyterian Medical Center

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The first demonstration of a circadian rhythm by Jean Jacques d’Ortous de Mairan in 1729

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Evening

4:30 am

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State Generators

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Neurochemical regulation of awake and sleep and REM and Non-REM

	Adrenergic
	Cholinergic
	Serotonergic
	Glutamatergic
	Dopaminergic

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REM  Sleep

	Characteristic EEG
	Variable heart and respiratory rates
	Muscle paralysis
	REM’s

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"Video"

	Video

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Sense of Humor
in Sleep Deprivation

	Gone

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REM Deprivation

	REM pressure
	REM rebound

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Snoring
and
Sleep Apnea

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