Hypothalamus and Limbic System

Lecture I:  The hypothalamus

Hypothalamus and Limbic System:  Homeostasis

Hypothalamus and Limbic System:  Emotion and Motivated Behavior

Hypothalamus and Limbic System:  Clinical Context

Hypothalamus  and Limbic System:  Clinical Context (cont.)

Hypothalamus:  Integrative Functions

Hypothalamus Anatomy

Hypothalamus Anatomy

The Paraventricular Nucleus

What pathways deliver visceral information to the hypothalamus?

What pathways control autonomic responses?

Hypothalamus:  Inputs and Outputs

Neural Input and Hormonal Output:  oxytocin release and lactation

Vasopressin release:  an example of humoral input and humoral output

Hormonal input and Neural output:  Endocrine Control of Behavior

What hypothalamic pathways influence endocrine function?

How do we know that regulatory factors travel through the portal circulation to the pituitary?

How do we know that regulatory factors travel through the portal circulation to the pituitary (2)?

Homeostatic processes:  servo-control systems

Temperature regulation is a good example of a hypothalamic servo-control system

Distinct regions of the hypothalamus mediate heat dissipation and heat conservation

Distinct regions of the hypothalamus mediate heat dissipation and heat conservation (2)

Endocrine responses to temperature change

Behavioral responses to temperature change

The hypothalamus integrates peripheral and central temperature information

Feeding behavior can also resemble a servo-control mechanism

Feeding behavior can also resemble a servo-control mechanism (2)

How does the hypothalamus contribute to the control of food intake?

How does the hypothalamus contribute to the control of food intake? (2)

How does the hypothalamus contribute to the control of food intake? (3)

A model for energy homeostasis

A model for energy homeostasis

How do satiety signals control meal size?

Hypothalamic neuropeptides that influence caloric homeostasis

Hypothalamic neuropeptides that influence caloric homeostasis (2)

Leptin deficiency disrupts the normal developmental pattern of projections from the arcuate nucleus to PVN in mice

Leptin treatment during development can rescue projections from the arcuate nucleus to PVN

Effects of leptin on hypothalamic neurocircuitry

Summary of Hypothalamus Lecture