General Features of Synapse
Formation
1) The pre- and post-synaptic cell organize each
others organization (bi-directional signaling)
2) Synapses mature during development
 widening of synaptic cleft, basal lamina
 transition from multiple innervation to 1:1
3) Muscle and nerve contain components
required for synaptogenesis (vesicles,
transmitter, ACh-R)
ŕ  “reorganization”