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| The exciting
news: CNS neurons can sprout or
grow. |
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| Challenges: |
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| *Overcome
the “bad” glial environment: |
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| - combat glial scars, inhibitory
extracellular matrix |
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| - add blockers of myelin |
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| - repopulate with neurons and “good” glia |
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| *Help
axons regrow: |
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| add neurotrophins (increase cAMP
levels to prime neurons |
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| to
ignore myelin-inhibitors). |
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| re-express ”youth" proteins -
GAP-43 |
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| *Induce
reformation of synapses (least understood step); |
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| how do normal synapses form? |
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