Adenocarcinoma

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A 70 year old man experienced bright red blood per rectum and was found to have iron deficiency anemia. He underwent colonoscopy that revealed a large, fungating, friable mass in the sigmoid colon. The patient underwent a sigmoid colectomy.

Questions

1. What are the histological characteristics of this mass?
2. What is the diagnosis?
3. What is the relationship of this lesion to the one seen in slide 4 (Adenoma)? See description of morphologic and molecular changes.

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