Rapid Cycling Bipolar Disorder
n Derived from studies of lithium failure
n Definition: 4 or more episodes, last 12 months
n Prevalence = 15% of BPD patients
n Not a stable phenotype
n Predictors:
n female gender
n antidepressant use
n thyroid disease
Dunner and Fieve, 1974. Dunner 1979; Winokur 1969
Women and Bipolar Disorder