| 3α Reduced Neurosteroids |
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| n | Progesterone
metabolites : |
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| n | Allopregnanolone
(3, 5 TH Progesterone) |
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| n | 3, 5 TH
deoxycorticosterone |
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| n | Pregnanolone
(3, 5 TH Progesterone) |
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| n | Allosteric
regulation: At nM concentrations, |
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| increase
frequency and duration of GABA-induced |
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| channel
opening. Most potent known
endogenous |
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| positive
allosteric regulator of GABAA |
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| n | Direct
agonism: At μM concentrations, produce |
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| Chloride
influx without GABA |
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| Women and
Bipolar Disorder |