Evidence for a 5HT/Estrogen
Connection
n PMDD responding to luteal SSRI use
n SSRI>TCA in postpartum depression:
n PPD less response to TCA than non post-
partum depression.
n Open label response rates: 67% TCA, 79% SSRI.
n 8 week open label sertraline: 95% response rate,
66% remission.
n Women may be more sensitive to tryptophan
depletion
Women and Bipolar Disorder