The Neurobiology of Suicidal Behavior

Suicidal Behavior

Suicidal Behavior

Magnitude of the Problem

Demographics

Relationship to Psychiatric Illness

Vulnerability or Diathesis for Suicidal Behavior

Vulnerability or Diathesis for Suicidal Behavior

A Stress Diathesis Model

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Where Does Neurobiology Fit In?

Serotonergic Activity is Related to Aggression/Impulsivity and Suicidal Behavior

Norepinephrine Relates to Hopelessness

Mapping the Pathobiology of Depression and Suicide

Serotonin System Dysfunction: Independent correlations with  suicidal behavior and depression

Markers of Serotonin Input: Presynaptic markers

Postmortem Cortical Brain Mapping in Suicide and Depression

Serotonin Responsivity

PET Measures of PFC Activity and Depression or Suicidal Behavior

Why are Serotonin Responses Abnormal in that Part of the Brain?

Factors Influencing Suicide
Diathesis or Predisposition and Serotonin

Familial Transmission of Suicidal Behavior

Genetics of Suicide

Candidate Genes
From the Serotonin System in Suicide

Life Events or Stress and Suicide

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Neurobiology of Suicide Looks like a Stress Response

Parenting, Suicide and Psychopathology

Drug Abuse and Suicide

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Summary

The Future