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| Postmortem Cortical Brain Mapping in |
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| Suicide
and Depression |
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| • | Lower
serotonin transporter binding in Major |
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| Depression
is widespread in PFC. |
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| • | Lower
serotonin transporter binding in suicide is |
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| highly
localized to ventro-medial PFC. |
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| • | The
ventro-medial prefrontal cortex is involved in |
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| behavioral
and cognitive restraint. Therefore, |
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| deficient
serotonin input to that brain region |
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| could
predispose to acting on suicidal or |
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| aggressive
feelings. |
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