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| WHY IS THERE A DELAYED ONSET |
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| OF
ACTION of ANTIDEPRESSANTS |
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| • | SSRIs
cause gradual desensitization of 5-HT1A |
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| autoreceptors
without change in 5-HT1A |
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| postsynaptic
terminal field receptors, gradually |
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| amplifying
the serotonin signal. |
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| • | ECS
causes progressive postsynaptic 5-HT1A |
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| receptor
upregulation, without effect on |
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| autoreceptors. |
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