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Seems
hyperactive. But since there are fewer noradrenergic
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neurons,
this can lead to a deficiency.
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Adverse
childhood experiences can produce an over-active
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responsiveness
in this system that persists into adulthood.
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In
situations that most people may not find too stressful, the
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vulnerable
depressed individual does feels very stressed and
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may
deplete NE. Depletion of NE with AMPT causes
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depression
in recovered patients but not normals.
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Restraint
stress in animals causes NE depletion and
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hopelessness. Hopelessness is part of major depression.
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