Fewer GABA Neurons in Anterior
Cingulate and Entorhinal Cortex in Bipolar
Disorders
27% fewer GABA cells in layer II of bipolar group.
No statistically significant difference in pyramidal cells or
glia.
No difference in size of pyramidal cells.
Indicates deficit in local circuit neurons or GABA cells in
layer II of anterior cingulate in bipolar disorders.
Benes et al., Biological Psychiatry 2001;50:395-406
Similar results reported by others in entorhinal cortex.