n Dose and time response of stressor influences immune effects, which in animals have affected lymphocyte responses, T-cell suppression, delayed hypersensitivity, GvH response, and NK activity n Social isolation:  decreased proliferative responses, NKCA, macrophage- mediated cytotoxicity, increased tumor metastases. n Stressor predictability and control over stressor influence immune effects;  fear determines level of immunosuppression.
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