 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| n |
Adult rats
subjected to neonatal handling
|
|
|
u |
Decreased HPA
axis responses to stress
|
|
|
|
« |
mediated by
up-regulation of
|
|
|
glucocorticoid
receptors in the
|
|
|
hippocampus
(Meaney et al)
|
|
|
| n |
Rat pups sep.
from mothers in 1st 3 wks
|
|
|
have higher
corticosterone levels and
|
|
|
greater cort
responses to acute stress.
|
|
|
| n |
Chronic stress
can result in damage to
|
|
|
hippocampal
neurons due to high
|
|
|
circulating
corticosterone levels
|
|
|
| n |
Increased CRF
may result from maternal
|
|
deprivation,
increase risk of depression
|
|
|
(found in adult
monkeys whose mothers
|
|
|
were subjected
to variable foraging
|
|
|
conditions—Coplan
et al, 1996)
|
|
